Introduction: One of the goals of professional nurses is to provide patient’s comfort. This is achieved through an understanding of the possible need for scientific, humanistic, ethical and communication care. Thus, how to identify comfort in hemodialysis patients is necessary, because it seems to be a constant presence in the ward. Therefore, this study aimed to "clarify the understanding and experience of patients undergoing hemodialysis nurse caring behaviors in comfort of hemodialysis patients". Method: This qualitative research was conducted with approaches and methods of content analysis. Purposive sampling began and continued until data saturation. Research environment of hemodialysis was at the Hamadan University of Medical Sciences. Collected data and conducted semi-structured interviews with 24 patients reached until saturation. Data were analyzed using qualitative content analysis in eight steps. Results: Main themes extracted from the data included “understanding the caring-humanistic needs”. The categories included "monitoring patients" and “having humanistic relationship”, "having a professional responsibility, “knowledge” and “having job experience” each of which has several sub-categories, respectively. Conclusion: We understand and respect the need for nurses to patient care and how to handle them in order to provide appropriate supportive measures, the measures that have an important role in the convenience of these patients, during hemodialysis.